MetabolicdiseaseisassociatedmorecloselywiththeaccumulationofaBDominaladiposeinspecificvisceraldepots.Recentstudieshaveimplicatedomentalandmesentericadiposetissueinobesity-relatedinsulinresistance,atherosclerosis,andtype2diabetes.Toprovidethemostrelevantsystemsforinvestigatingobesity-relatedmorbidities,Zenbioisofferingvisceralderivedhumanpreadipocytesandculturedadipocytestotheresearchcommunity.
Preadipocytesareisolatedfromomental,mesenteric,orperirenaladiposetissueandaretestedfortheirABIlitytodifferentiateinculturetomatureadipocytes.Preadipocytesareavailablecryopreservedorplatedandmatureadipocytesareavailableinavarietyofplatedformats.
Mostcellsarederivedfromobesenon-diabeticpatients(BMI>30),buttherearelimitedquantitiesofpreadipocytesandadipocytesfrompatientsofBMI<27aswellassomelotsofcellsavailablefromdiabeticpatients.LotsderivedfrommultiplepatientsarealsoavailableasPooled-orSuper-lots.
Therearelimitedquantitiesofdonormatchedomentalandsubcutaneouspreadipocytesorculturedadipocytesforstudiescomparingthetwodepots.
OMENTALADIPOSE
Thegreateromentumisthelargestperitonealfoldwithintheabdomenandhasanimmunologicfunction.Theomentumaidsinisolatingperitonealinfectionandabsorbingcontaminantsthroughthemesothelialstomata.Adipokinesandfattyacidsfromthisdepothavedirectaccesstotheliverthroughtheportalcirculationwhichmayleadtohepaticdysfunction.
MESENTERICADIPOSE
Mesentericadiposelieswithinthethinlayersoftheperitonealmesotheliumconnectingthesmallandlargeintestine.Adiposeaccumulationwithinthisdepotcorrelateswithanincreasedriskofmetabolicdisease.
PERIRENALADIPOSE
Perirenaladiposeresidesnearthekidneysoutsidetheperitonealcavity.Fatfromthisdepothasnotbeencorrelatedwithincreasedriskformetabolicdisease.
Speciallyformulatedmediaareavailableforusewithouromentalpreadipocytesandadipocytes.
