Adipocytes(fatcells)expressavarietyofproteinsthatfunctioninthehomeostaticcontrolofglucoseandlipidmetabolism.Insulinregulatesthetranslocationandsecretionofmanyoftheseproteinsinresponsetochangesinenergybalance.Adipocytecomplement-relatedproteinof30kDa(Acrp30),nowknownasadiponectin,isaproteinwhosesecretionfromadipocytesisenhancedbyinsulinstimulation.
Ithasbeensuggestedthatthedevelopmentofnon-insulindependent(TypeII)diabetesmayinvolvedysregulationofadiponectinsecretion(1).InsupportofthelinkbetweenobesityandTypeIIdiabetes,ithasbeenshownthatdecreasedexpressionofadiponectincorrelateswithinsulinresistance(2,3),andthatadiponectinappearstobeapotentinsulinenhancerlinkingadiposetissueandwhole-bodyglucosemetabolism(4).
- Nemet,D.,etal.(2002)Relationshipsamongadiponectinandotheradiposecytokines,bodycomposition,andfastinginsulininlowersocioeconomicmiddleschoolchildren.AmericanPhysiologicalSociety"s(APS)Abstracts.
- YamauchiT.,etal.(2001)Thefat-derivedhormoneadiponectinreversesinsulinresistanceassociatedwithbothlipoatrophyandobesity.NatureMedicine,Aug;7(8):941-6
- Kubota,N.,etal.(2002)Disruptionofadiponectincausesinsulinresistanceandneointimalformation.JBiolChem.277(29):25863-6(Epub2002May24).
- BergA.H.,etal.(2001)Theadipocyte-secretedproteinAcrp30enhanceshepaticinsulinaction.NatureMedicine,Aug;7(8):947-53
ThishumanAdiponectinELISAkitisdesignedtomeasuretheconcentrationofhumanadiponectinfromhumanserum/plasma,humanadipocytes,orconditionedmedium.
